Tom ve Jerry, Mars'a giden bir uzay gemisine gizlice binince işler karışır. Oradaki Marslılarla tanışan ikili, bir dev robot olan "Invincitron" yardımıyla Dünya'yı istila etmeye kalkışan Marslılara karşı savaşıp, günlerini kurtarır.
Jeff Bennett
Dr. Gluckman / Martian Guard #1 / President (voice)
Corey Burton
Martian Scientist / Court Attendant / Eyes At Gate (voice)
Kathryn Fiore
Peep / Press Girl (voice)
Brad Garrett
Commander Bristle / Martian Guard #3 (voice)
Jess Harnell
Major Buzz Blister / Martian General / Worker #3 (voice)
Tom Kenny
Grob / Gardener #1 / Martian Guard #2 (voice)
Bill Kopp
Tom / Press Guy #1 (voice)
Rob Paulsen
Computer / Worker #1 / Worker #2 (voice)
Frank Welker
Spike (voice)
Billy West
Major Biff Buzzard / King Thingg / Gardener #2 (voice)
